Download Betrayal of Trust: The Collapse of Global Public Health by Laurie Garrett PDF

By Laurie Garrett

During this meticulously researched and finally explosive new ebook by way of the Pulitzer Prize-winning writer of the New York Times bestseller The Coming Plague, Laurie Garrett takes readers around the globe to bare how a sequence of capability and current public future health catastrophes shape a terrifying portrait of actual worldwide catastrophe within the making.

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Ch002 HALs MonoHALs and Di-HALs Tri-HALs Lowest cytotoxic concentration was the lowest concentration of the HAL in the concentration-response curve that induced a statistically significant reduction in cell density as compared to the concurrent negative controls. b The LC50 value is the concentration of the HAL, determined from a regression analysis of the data, that induced a cell density of 50% as compared to the concurrent negative controls. c The lowest genotoxic concentration was the lowest concentration of the HAL in the concentration-response curve that induced a statistically significant amount of genomic DNA damage as compared to the negative control.

D The SCGE 50% Tail DNA value is the HAL concentration determined from a regression analyses of the data that was calculated to induce a 50% SCGE Tail DNA value. a We compared the CHO cell toxic potencies of the HALs to other DBP chemical classes with their calculated cytotoxicity and genotoxicity indices. The cytotoxicity index was determined by calculating the mean LC50 value of all of the individual compounds of a single class of DBPs. The genotoxicity index was determined by calculating the mean SCGE genotoxic potency value, which is defined by the midpoint of the SCGE tail moment or the 50% Tail DNA values from the individual compounds within a single class of DBPs (22).

Mammalian Cell Cytotoxicity and Genotoxicity of HALs (24) Lowest Cytotoxic Conc. (µM) a LC50 (µM) b Lowest Genotoxic Conc. ch002 HALs MonoHALs and Di-HALs Tri-HALs Lowest cytotoxic concentration was the lowest concentration of the HAL in the concentration-response curve that induced a statistically significant reduction in cell density as compared to the concurrent negative controls. b The LC50 value is the concentration of the HAL, determined from a regression analysis of the data, that induced a cell density of 50% as compared to the concurrent negative controls.

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