Download Asthma and COPD, Second Edition: Basic Mechanisms and by Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen PDF

By Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen I. Rennard, Neil C. Thomson

The second one variation of bronchial asthma and COPD: simple Mechanisms and medical administration maintains to supply a different and authoritative comparability of bronchial asthma and COPD. Written and edited by way of the world's prime specialists, it is still a entire evaluation of the newest knowing of the fundamental mechanisms of either stipulations, in particular evaluating their etiology, pathogenesis, and coverings.
* each one bankruptcy considers bronchial asthma and COPD in side-by-side distinction and comparability - no longer in isolation - within the context of mechanism, triggers, tests, cures, and medical management
* offers the newest and so much accomplished understandings of the mechanisms of irritation in either bronchial asthma and COPD
* such a lot wide connection with basic literature on either bronchial asthma and COPD in a single source.
* Easy-to-read summaries of the newest advances along transparent illustrations

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Extra resources for Asthma and COPD, Second Edition: Basic Mechanisms and Clinical Management

Example text

N Engl J Med 349(15): 1414–22, 2003. 8. Strachan DP, Butland BK, Anderson HR. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ 312(7040): 1195–99, 1996. 9. Oswald H, Phelan PD, Lanigan A, Hibbert M, Bowes G, Olinsky A. Outcome of childhood asthma in mid-adult life. BMJ 309(6947): 95–96, 1994. Natural History 10. Jenkins MA, Hopper JL, Bowes G, Carlin JB, Flander LB, Giles GG. Factors in childhood as predictors of asthma in adult life.

Of note, airway infections may also affect lung function decline through mechanisms that are independent of (and may indeed precede) the presence of COPD. Burrows and coworkers reported that smokers who recalled a history of “respiratory trouble” before 16 years of age had significantly steeper rates of decline in lung function as compared with those with no such history [92]. This effect was independent of a current or past diagnosis of asthma. It thus appears that intrinsic factors that modify the effects of smoking may be related to events occurring during the first years of life.

Nevertheless, it is now apparent that there is quite significant tracking between the level of lung function measured shortly after birth and that measured during childhood [53, 54], adolescence [22], and up to young adulthood [55]. This may explain, at least in part, the strong association between lower respiratory illness Natural History in early life and level of lung function in late childhood and early adulthood (see the discussion below). The factors that determine growth of lung and airways in utero are only partly understood.

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