Download Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung PDF

By Kian Fan Chung

During this ebook, best researchers in drugs and molecular pharmacology clarify the mobile mechanisms that keep watch over airway delicate muscle. The ability through which those are disrupted in sickness, and the pharmacologic thoughts in which they're converted are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the freshest info on one of many middle physiological techniques in airway disorder, and gives insights into present and destiny techniques to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most up-to-date examine to bronchodilator therapyMulti-contributed textual content, co-coordinated by way of of the top specialists within the box.

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A) Spontaneous motions of a representative bead show intermittent dynamics, with periods of confinement alternating with hopping; a bead glued to the coverslip is taken to represent the upper limit of measurement noise (bottom left). (B) MSDb calculated from Equation 1 is shown for representative beads. (C) The histograms of diffusion coefficient D* and exponent ␣ estimated from a least-square fits of a power-law (Equation 2) to the MSDb data. 6 ); beads attached to a cell seeded on a micropatterned substrate (50 ␮m x 50 ␮m), on which it could adhere but not crawl, exhibited the same anomalous motions.

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2000). Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2149–2153. , Fabry, B. et al. (2005). Cytoskeletal remodelling and slow dynamics in the living cell. Nat Mater 4, 557–561. , Trepat, X. et al. (2007). Cytoskeleton dynamics: fluctuations within the network. Biochem Biophys Res Commun 355, 324–330. Butler, J. , Tolic-Norrelykke, I. , Fabry, B. et al. (2002). Traction fields, moments, and strain energy that cells exert on their surroundings.

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