By Jan Lotvall
Aimed toward experts in breathing drugs, this new e-book comprehensively reports the diversity of brokers at present to be had for therapy of bronchial asthma, COPD, and different airway illnesses and covers functional directions in addition to demanding situations and problems of their use. Advances together treatment for bronchial asthma and COPD is the 1st ebook to handle the complexity of multi-agent remedy and take care of administration matters in an built-in style. A evaluate of at present to be had brokers and their purposes, in addition to new cures quickly to turn into on hand are defined. benefits of mixed remedies and extra concerns that come up from multi-agent courses are highlighted.
Chapter 1 Similarities and ameliorations within the pathophysiology of bronchial asthma and COPD (pages 1–15): J. Christian Virchow
Chapter 2 Glucocorticoids: Pharmacology and Mechanisms (pages 16–37): Peter J. Barnes
Chapter three Inhaled Corticosteroids: medical results in bronchial asthma and COPD (pages 38–52): Paul M. O'Byrne and Desmond M. Murphy
Chapter four LABAs: Pharmacology, Mechanisms and interplay with Anti‐Inflammatory remedies (pages 53–80): Gary P. Anderson
Chapter five lengthy‐ And Ultra‐Long‐Acting β22‐Agonists (pages 81–101): Mario Cazzola and Maria Gabriella Matera
Chapter 6 the protection of Long‐Acting Beta‐Agonists and the advance of blend remedies for bronchial asthma and COPD (pages 102–134): Victor E. Ortega and Eugene R. Bleecker
Chapter 7 Inhaled mix remedy with Glucocorticoids and Long‐Acting β2‐Agonists in bronchial asthma and COPD, present and destiny views (pages 135–153): Jan Lötvall
Chapter eight Novel Anti‐Inflammatory remedies for bronchial asthma and COPD (pages 154–202): Paul A. Kirkham, Gaetano Caramori, okay. Fan Chung and Ian M. Adcock
Chapter nine Novel Biologicals by myself and together in bronchial asthma and hypersensitive reaction (pages 203–231): Sharmilee M. Nyenhuis and William W. Busse
Chapter 10 Anti‐Infective remedies in bronchial asthma and COPD (pages 232–267): Jonathan D. R. Macintyre and Sebastian L. Johnston
Chapter eleven Long‐Acting Muscarinic Antagonists in bronchial asthma and COPD (pages 268–295): M. Diane Lougheed, Josuel Ora and Denis E. O'Donnell
Chapter 12 Phosphodiesterase Inhibitors in Obstructive Lung illness (pages 296–310): Jan Lötvall and Bo Lundbäck
Chapter thirteen organic treatments in improvement for COPD (pages 311–332): J. Morjaria and R. Polosa
Chapter 14 ‘Triple remedy’ within the administration of COPD: Inhaled Steroid, Long‐Acting Anticholinergic and Long‐Acting β2‐Agonist (pages 333–342): Ronald Dahl
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Additional resources for Advances in Combination Therapy for Asthma and COPD
Am J Respir Crit Care Med 2000;162:7–13. 49. Torrego A, Pujols L, Roca-Ferrer J, Mullol J, Xaubet A, Picado C. Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity. Am J Respir Crit Care Med 2004;170:420–5. 50. Sousa AR, Lane SJ, Soh C, Lee TH. In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosphorylation of JUN N-terminal kinase and failure of P1: OTA/XYZ JWST083-02 P2: ABC JWST083-L¨otvall 36 51. 52. 53.
69 This may be important for the non-bronchodilator effects of ␤2 -agonists, such as mast cell stabilization. 70 There is also evidence that ␤2 -agonists may affect GR and thus enhance the antiinﬂammatory effects of glucocorticoids. 72 This suggests that ␤2 -agonists and glucocorticoids enhance each other’s beneﬁcial effects in asthma therapy. 10 Conclusions There is now a much better understanding of how glucocorticoids act so effectively in asthma and also why they are relatively ineffective in COPD, based on a better understanding of their molecular mechanisms.
48. Gagliardo R, Chanez P, Vignola AM, et al. Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma. Am J Respir Crit Care Med 2000;162:7–13. 49. Torrego A, Pujols L, Roca-Ferrer J, Mullol J, Xaubet A, Picado C. Glucocorticoid receptor isoforms alpha and beta in in vitro cytokine-induced glucocorticoid insensitivity. Am J Respir Crit Care Med 2004;170:420–5. 50. Sousa AR, Lane SJ, Soh C, Lee TH. In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosphorylation of JUN N-terminal kinase and failure of P1: OTA/XYZ JWST083-02 P2: ABC JWST083-L¨otvall 36 51.